منابع مشابه
Data-driven modeling of Alzheimer disease pathogenesis.
Alzheimer Disease (AD) is the most prevalent form of dementia and the sixth leading cause of death in developed world. A substantial amount of data concerning the pathogenesis of this neurological disorder is available, but the complexity of the interactions they reveal makes it difficult to reason about them. This paper describes a computational model that represents known facts concerning AD ...
متن کاملP189: The Role of Periodontitis in Alzheimer Pathogenesis
Alzheimer disease (AD), the most common cause of dementia, is an irreversible progressive neurodegenerative condition. It is characterized by the salient inflammatory features, microglial activation and increased levels of pro-inflammatory cytokines which contribute to the inflammatory states of the CNS. Accumulating data suggest the key role of inflammation in AD pathogenesis. In a prospective...
متن کاملRole of autophagy in the pathogenesis of Alzheimer disease.
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is o...
متن کاملSleep, circadian rhythms, and the pathogenesis of Alzheimer Disease
Disturbances in the sleep-wake cycle and circadian rhythms are common symptoms of Alzheimer Disease (AD), and they have generally been considered as late consequences of the neurodegenerative processes. Recent evidence demonstrates that sleep-wake and circadian disruption often occur early in the course of the disease and may even precede the development of cognitive symptoms. Furthermore, the ...
متن کاملDisruption of blood-brain barrier in Alzheimer disease pathogenesis
Blood-brain barrier (BBB) regulates transport of various molecules and maintains brain homeostasis. Perturbed intracellular Ca(2+) homeostasis and BBB damage have been implicated in the pathogenesis of Alzheimer disease (AD). Although receptor for advanced glycation end products (RAGE) is known to mediate Aβ transcytosis across the BBB, molecular mechanisms underlying Aβ-RAGE interaction-induce...
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ژورنال
عنوان ژورنال: Military Medical and Pharmaceutical Journal of Serbia
سال: 2007
ISSN: 0042-8450,2406-0720
DOI: 10.2298/vsp0711765p